ABSTRACT Synthetic polymeric constructions (SPCs) including the consensus sequence of the HIV-1 surface envelope glycoprotein gp120 V3 loop (GPGRAF) blocked the fusion between HIV-1 or HIV-2 infected cells and CD4+ uninfected cells. These SPCs also inhibited the infection of human CD4+ lymphocytes, macrophages, and CD4- intestinal cells, by unrelated isolates of HIV-1 and HIV-2. V3 SPCs represent therefore a new class of therapeutic agents which may inhibit the spread of a wide range of HIV isolates in infected individuals.
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