A novel non-leaching antibacterial bone cement was developed and evaluated. A furanone-containing antibacterial poly(methyl methacrylate) was synthesized and used to partially replace polymethyl methacrylate (PMMA) powder in the current poly(methyl methacrylate) bone cement. Flexural strength and bacterial viability test were used to evaluate the modified cements. Results showed that almost all the modified cements exhibited reduced flexural strength but increased modulus as well as antibacterial activity, as compared to the original poly(methyl methacrylate) cement. Increasing antibacterial moiety significantly enhanced antibacterial activity and modulus but also reduced flexural strength. The bromo-containing derivative showed a stronger antibacterial function than its chlorine-containing counterpart. The results also showed that the modified cement absorbed a slightly more water than the original cement. The leaching tests showed that the modified experimental cement demonstrated no leachable antibacterial component to both cells and bacteria. Within the limitations of this study, the modified poly(methyl methacrylate) bone cement may potentially be developed into a clinically useful bone cement for reducing in-surgical and post-surgical infection.