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Current Topics in Steroid Research   Volumes    Volume 1 
Abstract
Cytosol-based ligand-binding assays and paraffin section immunocytochemistry for ER and PR detection in breast cancer: the time has come for more objectivity
Jacques Goussard
Pages: 153 - 157
Number of pages: 5
Current Topics in Steroid Research
Volume 1 

Copyright © 1998 Research Trends. All rights reserved

ABSTRACT
 
The importance of receptor level in breast cancer as an indicator of hormone response has been extensively studied for more than twenty years. Besides cytosol-based ligand-binding assays (dextran-coated charcoal assay, DCC), new methods using monoclonal antibodies raised against estrogen and progesterone receptors allow for the detection of receptors both in cytosol extracts (enzyme immunoassay, EIA) and in tissue sections (immunocytochemical assay, ICA). The biochemical assays (DCC and EIA) as well as the immunochemical detection (ICA) have specific qualities and produce original informations which are usefull for the therapeutic decision. While DCC gives a measure of receptor level, whatever the real source of synthesis (normal and/or neoplastic tissue), ICA locates the positive cells and their relative proportion in the tumor. Both methods present their own advantages and disadvantages which are summarized in this study.
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