Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Current Trends in Immunology   Volumes    Volume 1 
Abstract
DNA vaccines for infections with intracellular bacteria
Yukio Koide, Toshi Nagata, Atsushi Yoshida, Masato Uchijima
Pages: 123 - 132
Number of pages: 10
Current Trends in Immunology
Volume 1 

Copyright © 1998 Research Trends. All rights reserved

ABSTRACT
 
DNA vaccines could have potential advantages over other types of vaccines that the vaccines can induce strong cellular immune responses, cytotoxic T lymphocytes (CTL) and Th 1 cells, without resorting to live organisms or complicated protein formulation. The cellular immune responses are especially required for the protection against the infections with intracellular bacteria, suggesting that the pathogens seem to be suitable targets of DNA vaccines among bacteria. However, their application to bacterial infections have been less well documented. We constructed a DNA vaccine in which the bacterial codon usage was optimized DNA vaccine could induce CTL and protective immunity against Listeria monocytogenes. So far, DNA vaccine has been mainly applied to tuberculosis. We showed in this paper that codon bias in Mycobacterium tuberculosis, unlike any other bacteria, is comparable to those in Mus musculus and Homo sapiens, suggesting that condon-optimization is not required for the DNA vaccine against tuberculosis. In the construction of DNA vaccines against bacteria, attempts should be made to increase translational efficiencies of bacterial genes in the DNA vaccines by optimization of condon usage and by changing the translation initiation sequence to the optimal sequence defined by Kozak.
Buy this Article


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms