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Current Topics in Biochemical Research   Volumes    Volume 1 
Abstract
Roles of UGA in mammalian protein synthesis: selenocysteine, stop, suppression and reading gaps
Easwari Kumaraswamy, Xue-Ming Xu, Francisco J. Martin-Romero, Bradley A. Carlson, Dolph L. Hatfield
Pages: 113 - 123
Number of pages: 11
Current Topics in Biochemical Research
Volume 1 

Copyright © 1999 Research Trends. All rights reserved

ABSTRACT
 
Of all the code words in the genetic code, UGA serves more functions than any other codon. In mammals, it dictates insertion of selenocysteine (Sec) into the growing polypeptide chain and termination of protein synthesis. It may also be suppressed by a variety of aminoacyl-tRNAs and be involved in translational reading gaps, thus extending protein synthesis beyond the UGA termination signal. Each of these roles of UGA in mammalian protein synthesis is discussed.
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