Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Trends in Developmental Biology   Volumes    Volume 1 
Fetal cardiac control genes: implications for postnatal heart growth and heart disease
Alexander T. Mikhailov, Beatriz Nespereira, Mario Torrado
Pages: 27 - 38
Number of pages: 12
Trends in Developmental Biology
Volume 1 

Copyright © 2005 Research Trends. All rights reserved


Insight into cardiac development is bound to have a direct impact on our understanding of human heart disease in many ways. Recent studies point to the importance of the transactivation of cardiac control genes, which are stress-responsive regulators of gene expression during both postnatal heart development and heart failure progression. Based on the results of our research, we have targeted three fetal control genes, which are redeployed in the postnatal heart in response to stress signals that can provoke cardiac dysfunction and heart failure: (1) cardiac ankyrin repeat domain 1 protein (ANKRD1), (2) myocardin, and (3) homeo-domain only protein (Hop). Using a minimally-invasive model of experimentally controlled cardiomyopathic propagation in neonatal piglets in combination with expression display analyses, we have demonstrated the augmentation of the ANKRD1 and myocardin transcript and protein, not only during postnatal cardiac development, but also in failing myocardium. We additionally extended the clinical significance of this work by detecting augmented ANKRD1 and myocardin levels in cardiac samples obtained from patients with end-time cardiomyopathies. We also showed that expression of Hop, an antagonist of myocardin activity, is diminished in human failing myocardium. Our goal is also to identify common pathways in the developmental networks of these genes that can be reproduced in normal and cardiomyopathic settings in the postnatal heart. It is intriguing to speculate on how the transcription of ANKRD1, myocardin and Hop become permissible in postnatal hearts and how it can be influenced by physiological and pathological signaling.

Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms