Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Trends in Developmental Biology   Volumes    Volume 1 
Abstract
Oxidative stress and antioxidant defenses in neonatal biology
Hirokazu Tsukahara
Pages: 65 - 69
Number of pages: 5
Trends in Developmental Biology
Volume 1 

Copyright © 2005 Research Trends. All rights reserved

ABSTRACT

The fetal-to-neonatal transition is characterized by physiologic and metabolic changes that are accompanied by a marked increase in the availability of oxygen to the body. Consequently, the pro-oxidant status may cause oxidative stress in neonates. In particular, sick preterm neonates are exposed to increased    oxidative    stress    after    birth   because of exposure to supra-physiological oxygen concentrations in combination with reduced antioxidant defenses. However, few methods can determine the degree of oxidative stress in neonates both directly and quantitatively. Reactive oxygen species (ROS) can damage all types of biomolecules; oxidative damage to DNA, lipids, and proteins can be deleterious and concomitant. Recently, specific biomarkers for oxidative damage and antioxidant defenses have been introduced into perinatal medicine. This review specifically     addresses     pathophysiological    roles of  oxidative  stress  in  neonates  and  presents results of our recent studies on evaluating their oxidative stress status. This review also provides data for antioxidant systems in neonates. Such information will be helpful to  understand   the   pathogenesis   and   management of ROS-associated neonatal diseases, including respiratory distress syndrome and active retinopathy.

Buy this Article


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms