Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Trends in Developmental Biology   Volumes    Volume 1 
A radical formation of mammalian cumulus-oocyte complex matrix: Synthetic regulation and possible roles of hyaluronan (HA) and HA-binding protein in oocyte meiotic maturation
Eimei Sato, Kiyoshi Totsukawa, Naoko Kimura
Pages: 131 - 147
Number of pages: 17
Trends in Developmental Biology
Volume 1 

Copyright © 2005 Research Trends. All rights reserved


In most mammals, the growth and development of the oocyte and its surrounding somatic cells occur in a highly coordinated and mutually dependent manner. The oocytes acquire their developmental competence sequentially during follicular growth, ultimately reaching the ability to undergo the complete meiotic and cytoplasmic maturation at the final stage of preovulatory follicle. Fully-grown immature oocytes are tightly surrounded by compact layers of specialized granulosa cells termed cumulus cells that form the cumulus-oocyte complex (COC). After a preovulatory surge of gonadotrophin, the cumulus cells organize a special muco-elastic extracellular matrix (ECM) that requires the synthesis and deposition of a large amount of hyaluronan (HA) and HA binding matrix glycoproteins. Many studies have reported that the formation of COC matrix mass plays important roles for a variety of reproductive aspects, oocyte meiotic maturation with changes of junctional communication and cytoskeletal modification in COC, ovulation, fertilization and early embryo development. Lately, we identified the expressions of HA synthases and HA receptor CD44 in porcine COC matrix. The interaction of HA-CD44 appears to be closely related to the gap junctional communication and meiotic resumption. This review points  to the  recent  findings  on the regulation and the presumptive mechanism of COC matrix molecules, and physiological features in COC expansion.

Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms