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Current Topics in Toxicology   Volumes    Volume 1 
Male reproductive toxicity of organophosphorate agropesticides
L. J. del Valle, E. Bustos-Obregón, H. R. Contreras
Pages: 125 - 133
Number of pages: 9
Current Topics in Toxicology
Volume 1 

Copyright © 2004 Research Trends. All rights reserved

The malathion and parathion are organophosphorate pesticides (OP) and they are widely used in the agriculture practices in the world. The toxicity produces by them is follow by the increase of acethylcholine (Ach) levels and decrease of acetylcholinesterase (AchE) activity in the serum. We have studied the effects of these OP on the function male reproductive to determine the kind of cellular affected in the environment testicular. Ours results demonstrated that these pesticides are power disruptors of testicular function and produce severe damage on the sperm, Sertoli and Leydig cells morphology and function. So, there is not once target testicular to the negative action of these reproductive disruptors. These agents induce teratozoospermia during the spermatogenesis, acrosome reaction and chromatin decondensation in sperm ejaculated. In the testis, the Sertoli cells are morphologically altered and Leydig cells produce low levels of testosterone it is showing a clear alterations in the androgenic pathway.  In global manner, the effects on the morphology and physiology testicular are interpreted as metabolic and morpho-structural disturbances. The mechanism that could explained the male reproductive risk is an general effect on the testis and there is not once cellular specific diana to these toxicants. Testicular toxicity can be a problem complex as the network self of testicular function
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