Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Current Trends in Medicinal Chemistry   Volumes    Volume 1 
Abstract
Studies on the α-adrenergic receptor: Structure-activity relationships
Gloria Resell, Mercedes Alvarez
Pages: 115 - 127
Number of pages: 13
Current Trends in Medicinal Chemistry
Volume 1 

Copyright © 1993 Research Trends. All rights reserved

ABSTRACT
 
The general synthetic methods and α-blocking activity in the rat vas deferens of a series of tetra- and diamine disulfides structurally analogues to benextramine as well as a serie of related compounds without the disulfide group are described. All compounds containing a central cystamine moiety displayed an irreversible α-adrenergic blockade at concentrations ranging from 10-4 to 6 x 10-6 M. Potency was increased in cystamines N, N` -disubstituted with 6-aminohexyl groups, especially when the outer nitrogen atoms bear arylalkyi substituents or are inclosed in a ring.
Buy this Article


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms