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Trends in Comparative Biochemistry & Physiology   Volumes    Volume 10 
A survey of the DNase I hypersensitive sites in a human transgenic PRM1→PRM2→TNP2 model system
Stephen A. Krawetz, Susan M. Wykes
Pages: 55 - 63
Number of pages: 9
Trends in Comparative Biochemistry & Physiology
Volume 10 

Copyright © 2004 Research Trends. All rights reserved


The two human protamines, PRM1, PRM2 and transition protein TNP2 orchestrate the molecular restructuring of the male haploid genome during the final stage of spermatogenesis.  The genes encoding these three proteins exist as a single chromatin domain flanked by two male, germ cell-specific MARs. Previously, we have shown that the temporal regulation of the PRM1→ PRM2→TNP2 domain is facilitated by the formation of a DNase I sensitive, potentiated conformation at the pachytene stage, prior to the haploid expression of the locus in round spermatids.  Extending this analysis, we present the preliminary identification of several DNase I HS sites in association with both the  5’ and 3’ protamine MARs.   A discussion of these results and their functional significance is presented.

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