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Trends in Developmental Biology   Volumes    Volume 11 
Abstract
Human erythrocytes are ill-adapted for the Western diet and may be a potential source of circulatory methylglyoxal, post-synthetic protein modification and type-2-diabetic complications
Alan R. Hipkiss
Pages: 29 - 32
Number of pages: 4
Trends in Developmental Biology
Volume 11 

Copyright © 2018 Research Trends. All rights reserved

ABSTRACT
 
It is suggested that excessive glycolysis within erythrocytes can promote the accumulation of methylglyoxal (MG) precursor dihydroxyacetone phosphate resulting from excessive catalytic activity of triosephosphate isomerase (TPI) which causes deamidation of TPI asparagine residues and eventual decline in catalytic activity. Consequently under conditions of excessive and continuous carbohydrate intake, and consequent high red cell glycolysis, it is suggested that the highly glycolytic erythrocytes could be a metabolic “Achilles’ heel,” not only accumulating MG but also delivering MG throughout the body.
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