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Current Topics in Toxicology   Volumes    Volume 11 
Impacts of chronic borax intoxication on the liver structure and its reparative regeneration
Yerbol Zhasulanovich Bekmukhambetov, Turakbay Zhetenovich Umbetov, Akzhenis Krimgereevna Berdalinova, Arip Kubekovich Koishibayev, Sara Bakhidzhanovna Makhambetova, Gulnar Dostanovna Sultanova, Mukhtar Sayinovich Zhailybaeb
Pages: 55 - 65
Number of pages: 11
Current Topics in Toxicology
Volume 11 

Copyright © 2015 Research Trends. All rights reserved

The impact of borax on the structure of the liver and its post-experimental reparative regeneration were studied on 110 outbred white male rats. The chronic intoxication of animals was carried out for two months by daily intraperitoneal administration of an aqueous solution of borax at a dose of 150 mg/kg. Histological sections were stained with hematoxylin and eosin, and with van Gieson’s stain. After a two-month intoxication of the organism with borax, the liver mass index reduced to 36.3 ± 2.52 (42.5 ± 2.37 in the control group). The experimental group showed signs of hepatocyte degeneration (12.3 ± 1.24). We also observed blood stasis, characterized by a blood filled central vein and dilated liver sinusoids. Interlobular veins were congested and extended peritubular spaces appeared around interlobular bile ducts. Binucleated cells grew up to 12.7 ± 1.75% (5.8 ± 0.41% in the control group) and the number of polyploid cells increased (4.3 ± 0.27%, with 2.2 ± 0.12% in the control group). During the post-experimental period (7 days, 14 days, 30 days, and 60 days), we observed a gradual reduction in the number of degenerating cells and an increase in the number of dark hepatocytes with a significant decrease in the numbers of binucleated and polyploid hepatocytes.
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