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Trends in Cancer Research   Volumes    Volume 11 
Crossroads of hallmarks in aging and cancer: Anti-aging and anti-cancer target pathways can be shared?
Kanya Honoki, Hiroki Kuniyasu, Shingo Kishi, Yasuhito Tanaka, Toshifumi Tsujiuchi
Pages: 39 - 59
Number of pages: 21
Trends in Cancer Research
Volume 11 

Copyright © 2016 Research Trends. All rights reserved

Most of the hallmarks proposed in cancer and aging are shared in terms of genetic pathways and biochemical processes. The dissection of the interconnection of the candidate hallmarks between cancer and aging could identify shared targets for improving human health. Here, we will focus on the 7 characteristic hallmarks both in cancer and aging, namely genetic instability, sustained proliferative signaling/loss of proteostasis, evading anti-growth signaling/epigenetic alteration, enabling replicative immortality and resisting programmed cell death/telomere attrition and cellular senescence, deregulating cellular energies/deregulated nutrient sensing and mitochondrial dysfunction, tumor promoting inflammation and avoiding immune destruction/altered intercellular communication, and tumor microenvironment/stem cell exhaustion. The current review identifies that most prominent targets are blocking NF-κB, inhibiting mTOR (mammalian target of rapamycin), IGF-1 (insulin-like growth factor 1) and PI3P (Phosphatidylinositol 3,4,5-trisphosphate)/Akt pathways, and these targets could cover all hallmarks shared by both anti-cancer and anti-aging properties. Based on this result, we will propose the possible approaches to target these pathways in order to achieve better health by reducing the risks of cancer and aging.
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