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Trends in Cancer Research   Volumes    Volume 11 
Clinical significance of the levels of platelet-derived microparticles, PAI-1 and HMGB1 as prognostic biomarkers for patients with non-small-cell lung cancer
Maiko Niki, Shosaku Nomura, Takashi Yokoi, Noriko Katashiba, Takeshi Tamaki, Yuichi Katashiba, Yoshitaro Torii, Toshiki Shimizu, Takayasu Kurata
Pages: 61 - 69
Number of pages: 9
Trends in Cancer Research
Volume 11 

Copyright © 2016 Research Trends. All rights reserved

We measured various biomarkers in non-small-cell lung cancer (NSCLC) patients in an effort to discover novel prognostic indicators. We identified three such markers, namely platelet-derived microparticles (PDMP), plasminogen activator inhibitor (PAI)-1 and high-mobility group box-1 (HMGB1). Using multivariate analysis, we assessed 147 NSCLC patients and 35 control patients and found that HMGB1 and PAI-1 levels were significantly correlated with those of PDMP. We also analyzed the contribution of the newly designed risk factor (NDRF) to overall survival (OS) or disease-free survival (DFS). NDRF classification was determined based on levels of PDMP, HMGB1 and PAI-1. To determine the individual prognostic power of PDMP, HMGB1 and PAI-1, we evaluated associations between their levels and patients outcome by Kaplan–Meier survival analysis in the derivation cohort. NDRF3 status (patients who had high levels of all of PDMP, HMGB1 and PAI-1) was significantly correlated with a poor prognosis (p < 0.05 for both OS and DFS). Our findings suggest that abnormal levels of PDMP, HMGB1 and PAI-1 are related to each other in NSCLC. Moreover, the vascular complications associated with these three markers may contribute to a poor prognosis for NSCLC patients.
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