Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Trends in Cancer Research   Volumes    Volume 11 
Abstract
Immunohistochemical study supports the targeting of HSP27 alone, or HSP27 in combination with AKT, as therapeutic strategies to treat SPARC+/PTEN-wt or SPARC+/PTEN-null gliomas
Laila M. Poisson, Sandra Cottingham, Aditya Raghunathan, Andrea Transou, Enoch Carlton, Stacey L. Thomas, Sandra A. Rempel
Pages: 99 - 139
Number of pages: 41
Trends in Cancer Research
Volume 11 

Copyright © 2016 Research Trends. All rights reserved

ABSTRACT
 
Secreted Protein Acidic and Rich in Cysteine (SPARC) promotes glioma migration and invasion, and does so, in part, by activating p38 mitogen activated protein kinase (P38 MAPK)–mitogen-activated protein kinase-activated protein kinase 2 (MK2)–heat shock protein 27 (HSP27) signaling. Phosphatase and tensin homolog (PTEN) suppresses SPARC-induced invasion, and decreases pAKT, serine (S)15- and S78HSP27. Therefore, SPARC function is affected by PTEN. Consequently, we propose targeting HSP27 in PTEN-wild-type gliomas, and both HSP27 and AKT in PTEN-null gliomas. Our in vitro studies support this therapeutic strategy; however, we do not know whether these pathways are reflected in human tumors. In this immunohistochemistry study, we examined SPARC, HSP27, and AKT expression and phosphorylation relative to tumor grade, to PTEN genetic status, to tumor invasion, and to patient survival. The results show that all glioma grades have elevated SPARC and S82HSP27. The expression of HSP27, S15HSP27, and S78HSP27, AKT and phospho (p)AKT increases with increasing grade. We found that the loss of PTEN correlates with increased HSP27, S15HSP27, S78HSP27 and pAKT. Finally, we observed that increasing levels of SPARC and pAKT correlate with shorter patient survival, as does any expression of S78HSP27. This study provides important rationale for targeting HSP27 alone, or HSP27 and AKT together, to treat glioma patients.
Buy this Article


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms