Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Trends in Endocrinology   Volumes    Volume 11 
Endocrine disrupting properties of dill seed essential oil in female mice
Sepideh Arbabi Bidgoli, Sahar Haghighi, Jinous Asgarpanah
Pages: 57 - 65
Number of pages: 9
Current Trends in Endocrinology
Volume 11 

Copyright © 2020 Research Trends. All rights reserved

Dill seed essential oil (DSEO) is a candidate for pharmaceutical and nutraceutical applications but the safety data is not available. In this study we aim to evaluate the acute and repeated dose toxicity of DSEO in female mice via histopathological and immunohistochemical evaluations with focus on reproductive organs. After providing DSEO and characterizing its chemical composition through gas chromatography-mass spectrometry (GC-MS), toxicity tests were performed in accordance with OECD 425 and OECD 407 guidelines, followed by additional immunohistochemistry tests on sex hormone receptors in reproductive organs of female mice. Acute tests did not show any mortality or signs of toxicity within the first 24 h and follow-up period. No-observed-adverse-effect-level (NOAEL) was determined as 25 mg/kg after daily administrations of 25, 250, 500, and 1000 mg/kg doses of DSEO in a 28-day regimen. Although the low dose (25 mg/kg) didn’t show any organ toxicity, this regimen caused significant decrease in serum estradiol levels [16.21(0.02) vs. 60.8(0.1) pg/ml, p < 0.001], significant uteri weight gain (0.075 g vs. 0.004 g, p = 0.004), and mild edema in endometrial tissues compared to control. Endometrial overexpression of estrogen receptor alpha (ERα) was further detected in DSEO treated animals. Primary anti-estrogenic effects of DSEO at low doses (25 mg/kg) suggest it as a future herbal supplement for preventive and therapeutic applications in clinical setting.
Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms