A previous method by which titania (TiO₂) nanoparticles in water could be encapsulated within lecithin liposomes was further investigated to determine whether polydopamine (PDA) coating was crucial to the encapsulation efficiency. Screening by flow injection analysis demonstrated the excellent homogeneity of PDA-TiO₂ nanoparticles. Encapsulation of PDA-TiO₂ nanoparticles at high concentrations by lecithin liposomes was validated by gel filtration chromatography with fluorescence detection. Transmission electron microscopy helped visualize the bimodal size distribution and morphology shape of the lecithin liposome-encapsulated PDA-TiO₂ nanoparticles. These findings promise a cost effective technology for the removal of metal oxide nanoparticles in water treatment using ultrafiltration membranes with 0.1 μm pore size.