Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Trends in Comparative Biochemistry & Physiology   Volumes    Volume 11 
Pharmacological properties of the developing chick myocardium
Hideaki Nouchi, Hikaru Tanaka, Koki Shigenobu
Pages: 37 - 45
Number of pages: 9
Trends in Comparative Biochemistry & Physiology
Volume 11 

Copyright © 2005 Research Trends. All rights reserved


The developmental changes in receptors and ion channels in the chick heart could be summarized as follows. 1) The responsiveness to autonomic transmitters is present from an early stage of embryonic development before functional innervation takes place; innervation appears to modify myocardial responsiveness to transmitters. 2) ß-Adrenergic stimulation-induced positive chronotropy and inotropy is present throughout embryonic and post-hatch development. During the few days just before hatching, the inotropic sensitivity is transiently low to b-adrenergic stimulation and histamine. 3) Basal levels of ventricular tissue cAMP increased during embryonic development, which was followed by the appearance of direct muscarinic negative inotropic responses after hatching. 4) The functional role of the sarcoplasmic reticulum in myocardial contraction increases during embryonic development. 5) The resting membrane potential increases during early embryonic development due to an increase in K+ conductance. The action potential duration gradually increases during the embryonic period followed by a decrease just after hatching. Many of these features are common with mammalian animal species, but some are characteristic of the chick myocardium. Thus, the developing chick heart provides an interesting model for studies on the basic properties of the heart and their regulation.

Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms