Application of the gas-liquid two-phase flow for flux enhancement during the microfiltration of aqueous titanium dioxide dispersions on aluminium oxide tubular membrane has been studied. This study focuses on the influence of liquid and gas flow velocity and feed concentration on flux and development of mathematical model for flux prediction. The results of experiments show positive effect of constant gas-liquid two-phase flow on the flux. From analysis of experimental results based on dead-end filtration model it may be concluded that two-phase flow seems to expand the particle cake as it increases both cake porosity and thickness, thus allowing higher fluxes. For the periodical gas flow the flux enhancement is not so significant and strongly depends on the periodical gas flow mode and on the concentration of dispersion used. On the other hand, there is no concentration for which air injection has no effect on the permeate flux. Mathematical model for flux prediction during the two-phase gas-liquid microfiltration has been developed. The results showed good agreement between model prediction and experimental data.