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Trends in Photochemistry & Photobiology   Volumes    Volume 12 
Abstract
Photophysical, photochemical and photobiological properties of anthraquinones isolated from a phototoxic vegetal species: Heterophyllaea pustulata
Laura R. Comini, Susana C. Núñez Montoya, Gustavo A. Argüello, José L. Cabrera
Pages: 17 - 36
Number of pages: 20
Trends in Photochemistry & Photobiology
Volume 12 

Copyright © 2010 Research Trends. All rights reserved

ABSTRACT
 
Studies undertaken on isolated photosensitizing agents from Heterophyllaea pustulata, a photo-toxic plant, which natural habitat is the North-western part of Argentina, are presented here. The carried out work involved several steps that were initiated with the chemical-structural study of their most important secondary metabolites. As a result, three flavonoids, one iridoid glycoside (asperuloside) and ten aglycone anthraquinones were identified. Through the study of the photo-physical, photochemical and photobiological properties of the anthraquinone derivatives, we concluded that they show good photosensitizing (type I and type II) characteristics. The performed toxicological assays in vivo showed a direct cause-effect relation between these metabolites and the reported phototoxicity for H. pustulata. Finally, a few words about the potential application of these photsensitizing compounds as antibacterial agents will be given.
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