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Current Trends in Polymer Science   Volumes    Volume 12 
New poly(ester amide)s containing glycolic acid units: Evaluation of biocompatibility
Luis J. del Valle, Francesc Sepulcre, Antonio Gámez, Alfonso Rodríguez-Galán, Jordi Puiggalí
Pages: 27 - 32
Number of pages: 6
Current Trends in Polymer Science
Volume 12 

Copyright © 2008 Research Trends. All rights reserved

Thermal polycondensation with formation of metal halide salts as a driving force has proved to be an interesting method to synthesize alternating poly(ester amide)s constituted by glycolic acid and ω-amino acid units. These new materials may be used for biomedical applications and consequently biocompatibility tests are essential to follow further developments. Cytotoxicity, cell adhesion and cell proliferation studies on a representative poly(ester amide) derived from 6-aminohexanoic acid have been carried out using either L929 (fibroblast type) and Hep-2 (epithelial type) cell lines. Furthermore, cell viability tests have been performed with liquid extracts of the polymer. Results are promising for future biological applications of the studied material.
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