This study aims to evaluate the antioxidant and phenolic content of Myroxylon peruiferum leaves aqueous extract (MPAE) and M. peruiferum leaves methanolic extract (MPME). The antioxidant activity of these extracts was tested by reducing power assay, hydrogen peroxide and DPPH radical scavenging. Total phenolic content was measured by the Folin-Ciocalteu method. The phenolic content was 237.2 ± 3.12 mg/g GAE for MPME and 228.0 ± 2.09 mg/g GAE for MPAE. These extracts showed a high ability to inhibit tested reactive species. MPME showed the lowest IC₅₀ values. The IC₅₀ values found were 64.79 µg/mL and 56.60 µg/mL in the DPPH assay; 183.48 µg/mL and 158.96 µg/mL for reducing power; 121.44 µg/mL and 97.01 µg/mL for hydrogen peroxide. This work reports for the first time the antioxidant activity of M. peruiferum. The antioxidant compounds of this plant are important for food industry, cosmetics and pharmaceutical preparations.