Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Current Topics in Toxicology   Volumes    Volume 12 
Abstract
In vitro genotoxicity and cytotoxicity of cefixime in human peripheral blood lymphocytes
Erman Salih İstifli, Mehmet Topaktaş
Pages: 33 - 40
Number of pages: 8
Current Topics in Toxicology
Volume 12 

Copyright © 2016 Research Trends. All rights reserved

ABSTRACT
 
Cefixime (CFX) is a third-generation cephalosporin antibiotic that is widely used to treat Neisseria gonorrhoeae infection. Although some studies have reported the genotoxic and cytostatic/cytotoxic effects of cephalosporins, to the best of our knowledge, no studies have been performed on the genotoxic and cytotoxic effects of CFX in eukaryotic test systems. A global consensus about the genotoxicity of cephalosporins is still not feasible. Thus, the aim of the present study was to evaluate the potential genotoxic and cytostatic/cytotoxic effects of CFX in human peripheral blood lymphocytes. In this study, CFX did not induce chromosome aberrations (CAs) at 24- and 48-hr treatment periods. However, it was obvious that CFX induced more chromosomal-type breaks compared to the chromatid types at both the 24- and 48-hr treatments. No significant increase in the mean sister chromatid exchange (SCE) values was observed for the 24- and 48-hr treatment periods; however, the maximum SCE number showed an excessive increase in some lymphocytes at the 48-hr treatment. CFX did not induce micronucleus (MN) formation at both treatment times. However, CFX significantly decreased the proliferation index (PI) and mitotic index (MI) for both the 24- and 48-hr treatment periods. Furthermore, CFX caused a concentration-dependent decrease in the nuclear division index (NDI) for the 48-hr treatment (r = -0.979, P < 0.05). Our study showed that CFX was not genotoxic in cultured human peripheral lymphocytes. However, the excessive induction of SCEs in single cells is indicative of its mutagenic potential. In addition, the cytostatic/cytotoxic effects of CFX may have deleterious effects on the immune system, which may increase the susceptibility of the patient against bacterial infections.
Buy this Article


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms