Phenol is naturally found in some food and animal wastes. It is used as a disinfectant, insecticide and in some pharmaceutical products. Propolis is a mixture of beeswax and resins. It has antimicrobial, anti-inflammatory, antioxidant and immunomodulatory effects. This study investigates the effect of propolis on sub-chronic phenol use-induced toxicity on the lymphatic system and complete blood cell count in rats by the assessment of serum immunoglobulin, total and differential blood cell count, and histopathological changes of thymus, spleen and lymph nodes. Eighty adult albino rats were divided into four groups; each group consists of twenty rats. The control group received water, the second group received phenol only, the third group received propolis and the fourth group received propolis with phenol for 90 days via gastric gavage. Phenol sub-chronic use led to toxicity manifestations such as a decrease in the serum immunoglobulin and blood cell count, disturbance in the differential white blood cell count, decrease in the body, thymus and spleen weights of rats associated with histopathological changes in thymus, spleen and lymph nodes that were improved by propolis administration. Concurrent use of propolis with phenol ameliorated its toxicity on the lymphatic system and complete blood cell count.