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Trends in Organic Chemistry   Volumes    Volume 13 
Abstract
Cadmium nitrate tetrahydrate: An efficient catalyst for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones. Improved conditions for the Biginelli reaction
Davood Azarifar, Fatemeh Soleimanei, Kaveh Khosravi
Pages: 11 - 16
Number of pages: 6
Trends in Organic Chemistry
Volume 13 

Copyright © 2009 Research Trends. All rights reserved

ABSTRACT
 
New application of cadmium nitrate tetrahydrate as the catalyst for an efficient synthesis of 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) from an aldehyde, β-keto ester and urea both in refluxing ethanol and under solvent-free conditions is described. This method is applicable to various aldehydes and the yields are significantly higher comparing to the classical Biginelli reaction conditions.
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