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Current Topics in Biotechnology   Volumes    Volume 13 
Molecular mechanisms of antimicrobial transport across the membrane by multidrug efflux pumps of the major facilitator superfamily in bacterial pathogens
Manjusha Lekshmi, Jerusha Stephen, Sreepriya Prakasan, H. Sanath Kumar, Manuel F. Varela
Pages: 1 - 15
Number of pages: 15
Current Topics in Biotechnology
Volume 13 

Copyright © 2022 Research Trends. All rights reserved

Bacterial pathogens confer virulence by resisting the inhibitory nature of antimicrobial agents during infection. Membrane transporters of the major facilitator superfamily (MFS) mediate the active efflux of structurally distinctive antimicrobial agents. Treatment failures in patients with bacterial infectious disease frequently involve multidrug efflux systems of the MFS. These multidrug transporters are energized by secondary active transport mechanisms involving conformational changes tied to drug transport catalysis to mediate efflux across the bacterial membrane. This review article briefly summarizes recent developments regarding the molecular nature of the MFS multidrug efflux in bacterial pathogens. These active transporter systems represent promising targets for biotechnological approaches to reduce the conditions that foster infections that are recalcitrant to chemotherapy.
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