Emerging population study revealed how SARS-CoV-2 infection involved many pathways to transcribe their own genetic material with consequent alteration of host transcriptional machinery. As reported for HIV virus and tuberculosis caused by Mycobacterium tuberculosis (MTB), (SARS-CoV-2 also induces alteration of lipid metabolism that plays a central role in several infectious diseases. In silico analysis is a promising approach for understanding biological events of infection and the possible consequences of clinical symptoms and complex diseases manifestation. In particular, we used an in silico approach to identify possible human RNA-binding proteins (RBPs) involved in alterations of lipid metabolism. Subtraction of RBPs, by conserved binding motifs on viruses genome, could reduce the cytoplasmic availability of these proteins inducing host perturbation in lipid metabolic pathways.