Inorganic nanoparticles often exhibit novel physical and chemical properties as their size are in the nanometer scale dimensions. Due to their insolubility, several aspects related to the toxic impact of exposure to inorganic nanoparticles on the human body and on the environment are unknown. Nanotoxicology is the science that studies the toxicity of nanomaterials and nanoparticles. The toxicity tests that utilize the Daphnia magna microcrustacean have appeared as a promising model for this area. For these reasons, the aim of this review is to report the applicability of D. magna as a model to evaluate titanium dioxide nanoparticles (TiO₂-NP), silver nanoparticles (Ag-NP) and gold nanoparticles (Au-NP). Then, we show that the D. magna model is a promising organism for the evaluation of acute and chronic toxicity of inorganic particles, due to high sensibility to environmental changes, simple handling and short life cycle and reproduction.