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Trends in Comparative Biochemistry & Physiology   Volumes    Volume 13 
Genome-based technology for discovery, identification and validation of insecticide and drug targets
Jian Sun, Natalya Griko, Mohamed Ibrahim, Xuebin Zhang, Lee A. Bulla Jr.
Pages: 1 - 10
Number of pages: 10
Trends in Comparative Biochemistry & Physiology
Volume 13 

Copyright © 2008 Research Trends. All rights reserved

Discovery of molecular targets for development of new insecticides and drugs is critical for successful control of a variety of insect pests and infectious diseases. The extensive databases for genome sequences of insect, microorganisms and viruses provide valuable information for identification of new targets.  Here, we report a discovery platform that utilizes bioinformatics, genomics and proteomics for high-throughput gene and protein target identification. The platform facilitates screening of customized cDNA libraries and the construction of protein expression panels. The customized gene libraries allow for gene-based selection of cell-surface proteins whose critical cellular functions are prioritized by their potential as insecticide targets. The protein expression panels contain individual transgenic insect cell lines formatted in multi-well plates, which are suitable for high-throughput screening of multiple insecticide targets. The advantage of the discovery platform is that it brings together genome- and proteome-based target identification and target-directed screening for validating the action of new compounds in cell-based assays.
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