Some heavy metals like Cu, Cd, Co, Pb, Zn, and Fe are indispensable for us in very small quantities and are essential for human life in low concentrations, but at higher content in foods they are hazardous and toxic for people. The article presents the estimation of heavy metal content in red and white varietal wines in different vintages from south Slovakia with protected designation of origin (PDO) “Južnoslovenská”. The white wine variety “Rizling vlašský” vintage 2007 (Riesling blanc), as well as the red variety “Frankovka modrá” vintage 2007 (Blaufrankisch), was determined by atomic absorption spectrometry (AAS). The amounts of Pb were found to be 59 µg.dm^-3 and 73 µg.dm^-3, respectively. The Cd content was 1.60 µg.dm^-3 and 1.79 µg.dm^-3, respectively and the content of Cu was 183 µg.dm^-3 and 262 µg.dm^-3, respectively. After 13 years the white wine variety “Rizling rýnsky” vintage 2020 (Rheinriesling) from the same PDO “Južnoslovenská” was tested and determination of the metals Pb, Cu, and Fe by Atomic Absorption Spectrometry with Electrothermal Atomization (AAS-ETA) was performed. The red wine variety “Frankovka modrá” vintage 2020 was tested by AAS-ETA. The metal amounts were Pb 10 µg.dm^-3, Cu 220 µg.dm^-3 and Fe 390 µg.dm^-3  in white and 66 µg.dm^-3 Pb, 420 µg.dm^-3 Fe and 195 µg.dm^-3 Cu in red wine. This study aimed to examine whether the wines in the different vintages vary according to the content of heavy metals. Data analysis showed no statistically significant differences and no contamination was found.