Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Trends in Immunology   Volumes    Volume 14 
Importance of mucosal epithelial cell responses in shaping host immunity to bacterial pathogens
Ryan McClure, Paola Massari
Pages: 1 - 22
Number of pages: 22
Current Trends in Immunology
Volume 14 

Copyright © 2013 Research Trends. All rights reserved

Epithelial cells occupy a unique position at the interface between the environment and the human body. Mucosal epithelial cells of various tissues are constantly exposed to a large number of microorganisms of both commensal and pathogenic nature. It has been acknowledged that epithelial cells of mucosal body surfaces play a large role in influencing whether host immune responses should be initiated against these microbial species, as well as the intensity and the outcome of such responses. In this review, the contribution of epithelial cells from four human mucosal sites in shaping host defense responses to a number of bacterial pathogens is discussed. Specifically, how mucosal epithelial cells from the oral cavity, the airways, the gut and the reproductive tract recognize and discriminate between commensal and pathogenic organisms via specific cell receptors is examined. How activation of these cells influences direct tissue defense mechanisms, via production of anti-microbial substances, and how epithelial cells communicate with host immune cells via production of inflammatory mediators is also examined. In the case of the reproductive tract, apparent gender-specific differences in host immune responses are addressed.
Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms