Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Trends in Immunology   Volumes    Volume 14 
TRAF6 as a critical regulator of B lymphocyte functions
Kelly M. Arcipowski, Gail A. Bishop
Pages: 45 - 52
Number of pages: 8
Current Trends in Immunology
Volume 14 

Copyright © 2013 Research Trends. All rights reserved

The adaptor protein tumor necrosis factor receptor-associated factor 6 (TRAF6) plays a central role in B cell activation pathways initiated by a wide variety of receptors, including members of the tumor necrosis factor receptor (TNFR) superfamily, Toll-like receptors (TLRs), cytokine receptors, and the Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1). TRAF6 has the most divergent receptor-binding TRAF-C domain among the TRAFs, and interacts with receptors in a manner distinct from that of other TRAFs. TRAF6 plays an important role in regulating a diverse range of processes in many cell types, including various important roles in the function of immune cells. This review focuses upon the molecular mechanisms of TRAF6 function in B lymphocyte activation, and the importance of TRAF6 in normal and pathologic B cell functions.
View Full Article  


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms