Tuberculosis is a serious infectious disease with extensive importance for public health. Currently about 2 billion people are infected with the etiological agent of tuberculosis, Mycobacterium tuberculosis. Skin color has been described as a risk factor in susceptibility for development of this disease. The objective of this study was to evaluate the cellular and humoral immunological profile of self-referred white individuals bearing tuberculosis, in comparison with self-referred black individuals bearing the disease. Statistically significant differences in cellular aspects such as cytokines and humoral profiles were not found between the two groups. The obtained results do not demonstrate association between skin color and immunological responses inducing susceptibility to tuberculosis.