Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Biotechnology   Volumes    Volume 14 
Synthesis of 2(5H)-furanone derivatives containing bromine or chlorine and their antibacterial evaluation
Xin Wen, Yuling Xu, Yong Chen, Rashed Almousa, Gregory Anderson, Dong Xie
Pages: 1 - 11
Number of pages: 11
Current Topics in Biotechnology
Volume 14 

Copyright © 2023 Research Trends. All rights reserved

This study reports synthesis and antibacterial evaluation of the compounds derivatized from 3,4-dihalo-5-hydroxy-2(5H)-furanones. The minimum inhibitory concentration to planktonic bacteria and biofilm inhibition assays were used to evaluate their antibacterial functions. Three bacteria species (Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus) were used for evaluation. It was found that the bromine-containing derivatives were higher in antibacterial activity than their chlorine counterparts. The 5-position derivatization with two intact bromine or chlorine atoms attached showed a higher antibacterial activity than those derivatized at the 4-position. The derivatives with hydrophobic groups attached exhibited significantly higher antibacterial activities than those with hydrophilic ones attached. It was also found that the synthesized derivatives were more potent toward Pseudomonas aeruginosa than Escherichia coli and Staphylococcus aureus.
Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms