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Current Trends in Endocrinology   Volumes    Volume 14 
Abstract
IGF2-omas: a cause of hypoglycemia in infants with solid tumors
Debora Braslavsky, Maria Gabriela Ballerini, Ayelen Martin, Maria Eugenia Rodriguez, Melina Gil, Florencia Martino, Marcelo Urbieta, Mercedes Garcia Lombardi, Ana Keselman, Maria Gabriela Ropelato, Patricia Pennisi, Ignacio Bergad√°
Pages: 47 - 53
Number of pages: 7
Current Trends in Endocrinology
Volume 14 

Copyright © 2023 Research Trends. All rights reserved

ABSTRACT
 
Persistent hypoglycemia in pediatric patients is usually secondary to congenital hormonal or metabolic disorders. We describe an infant with neuroblastoma and recurrent hypoglycemia. Western immunoblotting revealed high molecular weight IGF2 and Big IGF2 bands that progressively decreased in correlation with clinical improvement and normalization of blood glucose levels. IGF2-omas are a potential cause of hypoglycemia in infants with solid tumors without clear evidence of other common causes.
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