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Current Trends in Endocrinology   Volumes    Volume 14 
An update on the biochemical diagnosis of anterior pituitary hormone deficiency in neonates and children: basal assessment and dynamic tests
María Gabriela Ballerini, María Gabriela Ropelato
Pages: 103 - 118
Number of pages: 16
Current Trends in Endocrinology
Volume 14 

Copyright © 2023 Research Trends. All rights reserved

Anterior pituitary hormone deficiency could be isolated with only 1 hormone deficiency or combined with 2 or more hormone deficiencies (combined pituitary hormone deficiency, CPHD) of adrenocorticotropic hormone (ACTH), growth hormone (GH), thyroid-stimulating hormone (TSH), prolactin (PRL) and the gonadotropin follicle-stimulating hormone (FSH) and luteinising hormone (LH). Imaging studies and the patient’s phenotype can guide the diagnostic suspicion, with the biochemical approach being an important tool for confirmation. This is a critical review of the usefulness of baseline and functional tests in the diagnosis of ACTH, GH, TSH, LH and FSH deficiency in children, taking into account the limitations of current methods for hormone quantification.
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