Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Trends in Organic Chemistry   Volumes    Volume 15 
Abstract
Synthesis of some 1,2,3,6-tetrahydro-5-(4’-substituted)phenyl-1,1-dimethyl-3-oxo-pyridinium bromides
Glaucia M. S. Pinheiro, Roberto Rittner, Nelci F. Höehr
Pages: 25 - 31
Number of pages: 7
Trends in Organic Chemistry
Volume 15 

Copyright © 2011 Research Trends. All rights reserved

ABSTRACT
 
Some 1,2,3,6-tetrahydro-5-(4’-substituted)phenyl-1,1-dimethyl-3-oxo-pyridinium bromides were synthesized from the commercially available p-substituted phenacyl bromides and N,N-dimethyl- aminoacetone. The acetophenones were converted in the corresponding phenacyl bromides, which by treatment with N,N-dimethylaminoacetone gave nitrogen quaternary salts, which were turned in the 3-oxopyridinium bromides using sodium hydroxide, followed treatment with hydro-bromidric acid, in good yields. All compounds were fully characterized by 1H and 13C NMR spectral data and elemental analysis. The main goal for the synthesis of these intermediates is their further application in the synthesis of pyridostigmine derivatives, since pyridostigmine itself is widely used in the treatment of myasthenia gravis, and of Parkinson‘s and Alzheimer‘s diseases due to its AChE activity.
Buy this Article


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms