Angiogenesis is the formation of new blood vessels from existing ones. This process is important in several physiologic processes, such as embryonic development, placenta formation, and wound healing. However, angiogenesis also occurs in numerous pathologic conditions, including cancer, rheumatoid arthritis, obesity, diabetic retinopathy, age-related macular degeneration (AMD) and neurological disorders such as Parkinson and Alzheimer’s disease. Recently a number of agents that inhibit angiogenesis have been approved to treat diseases such as cancer and AMD. In this context, several studies have been conducted, showing the antiangiogenic effect of natural products, which makes them a potential candidate in the development of new antiangiogenic drugs. The purpose of this review is to describe the studies of natural products, focusing on the quinones, with antiangiogenic activity.