Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Trends in Physical Chemistry   Volumes    Volume 15 
Abstract
Real-time localization and nanospectroscopy of single epidermal growth factor receptors in live cells
Jung Y. Huang, Chien Y. Lin
Pages: 105 - 112
Number of pages: 8
Trends in Physical Chemistry
Volume 15 

Copyright © 2014 Research Trends. All rights reserved

ABSTRACT
 
In the present paper, we demonstrate a technique that can simultaneously localize single epidermal growth factor receptors (EGFRs) in live cells and record their spectra as well. This technique has the advantages of both single-molecule sensitivity and parallel detection. By exploiting the environment-induced spectral changes of fluorescently tagged EGFRs, we disclosed that the environments of EGFR dimers in activated cells differ from the environments of EGFRs in cells at rest. This simple approach could open a route for devising a large number of biologically relevant applications that offer the advantages of minimum perturbation and single-molecule parallel detection.
View Full Article  


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms