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Current Topics in Phytochemistry   Volumes    Volume 15 
Black currant anthocyanins and their metabolites inhibit 5-lipoxygenase and low density lipoprotein oxidation
Teresa Röhrig, Katharina Scherer, Laura Headley, Ludger Eilers, Jessica Müller-Albers, Andrea Engel, Christoph Weckbecker, Elke Richling
Pages: 107 - 117
Number of pages: 11
Current Topics in Phytochemistry
Volume 15 

Copyright © 2019 Research Trends. All rights reserved

Leukotriene formation, which is mediated by 5-lipoxygenase (5-LOX), and the oxidation of low-density lipoproteins (LDLs) have been shown to contribute to the development of atherosclerosis. Earlier studies have shown that both mechanisms are inhibited by polyphenols, especially anthocyanins. The rutinoside-conjugated anthocyanidins present in black currants (Ribes nigrum L.) have higher bioavailability than monosaccharide-conjugated anthocyanidins and may therefore be beneficial in reducing the risk of cardiovascular diseases. We investigated the in vitro inhibitory potentials of cyanidin-3-O-rutinoside and delphinidin-3-O-rutinoside against 5-LOX activity and LDL oxidation. Both anthocyanins were able to significantly inhibit 5-LOX activity and LDL oxidation. The investigated aglycones, cyanidin and delphinidin, showed a lower 5-LOX inhibitory potential, but were more potent at inhibiting LDL oxidation than their respective rutinosides. Furthermore, the inhibitory potentials of certain colonic degradation products of anthocyanins (protocatechuic acid, phloroglucinol aldehyde, vanillic acid, and gallic acid) were assessed. Gallic acid stimulated 5-LOX activity and was the only degradation product that was able to inhibit LDL oxidation. The other degradation products inhibited 5-LOX activity at high concentrations. Anthocyanins, anthocyanidins, and several of their degradation products demonstrated in vitro inhibition of mechanisms that contribute to atherosclerosis development.
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