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Different NMR techniques are used to test protein-ligand binding in drug screening. In this research we have addressed the use of 19
F-NMR, a powerful and highly sensitive technique, to measure the binding between fluorinated ligands designed via dynamic combinatorial library and β
-catenin as a promising target for antitumor drugs. Moreover, the same technique allowed us to illustrate the binding constant for one of the ligands by using a non-fluorinated competitor ligand.