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Current Topics in Analytical Chemistry   Volumes    Volume 15 
Determination of lead in biological samples and its effects on the health of people living in an area contaminated by steel mill waste in Brazil
Fabiana de Lima Coutinho, Sayonara Vieira de Azevedo, Renato Marçullo Borges, Fernanda Pereira Baptista Bergamini, Leandro Vargas Barreto de Carvalho, Jamila Alessandra Perini Machado, Maria de Fátima Ramos Moreira
Pages: 33 - 44
Number of pages: 12
Current Topics in Analytical Chemistry
Volume 15 

Copyright © 2023 Research Trends. All rights reserved

Steelmaking is an anthropogenic activity contributing to the emission of lead into the environment. Lead, a non-essential and bioaccumulative metal, can cause adverse effects on human health. This study aimed to assess the biomarkers of exposure (lead concentration in blood, plasma, and urine), effect (delta-aminolevulinic acid dehydratase (ALAD) activity), and susceptibility (polymorphism rs1800435) to lead in residents exposed to steel industry waste in a condominium in the city of Volta Redonda, Rio de Janeiro, Brazil. Lead levels were measured in blood (BPb), plasma (PPb), and urine (UPb) using a graphite furnace atomic absorption spectrometer (GFAAS), while ALAD activity, and genotyping by spectrophotometry and RT-PCR, respectively. Twenty-seven individuals were assessed who showed a mean blood lead of 2.13±0.80 µg dL-1, plasma lead equal to 2.80±2.61 µg L-1, urinary lead of 4.35±4.31 µg g-1 creatinine, and an ALAD activity of 24.45±8.28 U L-1. The genotypical frequencies for the polymorphism rs1800435 were ALAD 1-1 (92.52%), ALAD 1-2 (7.40%), ALAD 2-2 (0.00%), while their allelic frequencies were 96.30% for the wild-type allele c, and 0.0370% for the polymorphous allele g. The results suggest that those individuals were environmentally exposed to lead.
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