Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Trends in Cancer Research   Volumes    Volume 15 
Regulatory mechanisms of microRNAs in childhood acute lymphoblastic leukemia
Tania S. de Liz, Michele P. Rode, Tânia B. Creczynski-Pasa
Pages: 1 - 16
Number of pages: 16
Trends in Cancer Research
Volume 15 

Copyright © 2020 Research Trends. All rights reserved

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, occurring mainly in children three to five years of age. ALL is a complex disease that involves both B-lineage and T-lineage precursor cells. Several studies have shown that microRNAs (miRNAs) can be used as a new class of biomarkers for ALL. These small, single-stranded, non-coding RNA molecules regulate gene expression through direct interaction with specific messenger RNAs. This review aims to summarize data from studies on miRNA and childhood ALL and presents the results of a gene ontology enrichment analysis performed on gene sets regulated by miRNAs. Most studies reported that different miRNAs are involved in childhood ALL; miR-196b-5p, miR-128-3p, miR-223-3p, miR-181a-5p, miR-27a-3p, and miR-708-5p were the most frequent. These miRNAs regulate genes and biological functions related to hematopoiesis, cell death, and proliferation. Although some miRNAs are promising biomarkers for ALL diagnosis, their use in clinical practice is still a challenge. This review reveals the need for further investigations on the role of miRNAs in disease development, diagnosis, and prognosis.
View Full Article  


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms