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Current Topics in Phytochemistry   Volumes    Volume 16 
Copaiba oleoresin prevents obesity development and its hepatic complications in high-sucrose diet model
Luciana Ortega Telles, Bianca Sulzbacher da Silva, Angélica Macedo Borges Paulino, Valéria Dornelles Gindri Sinhorin, Gisele Facholi Bomfim, Camila Renata Corrêa, André Ferreira do Nascimento, Renata de Azevedo Melo Luvizotto
Pages: 55 - 63
Number of pages: 9
Current Topics in Phytochemistry
Volume 16 

Copyright © 2020 Research Trends. All rights reserved

This study was designed to determine whether copaiba oleoresin inhibits sucrose-induced obesity and its hepatic complications. Thus, male Wistar rats were divided into three groups (n = 6 each group): control (C), high-sucrose diet (HSD) and HSD with copaiba oleoresin (200 mg/kg/day by gavage). After 8 weeks of treatment, oxidative stress parameters such as catalase, superoxide dismutase (SOD), reduced glutathione (GSH), glutathione S-transferase (GST), vitamin C (Vit C), carbonylated protein and lipid peroxidation were evaluated in the liver. Also, steatosis was determined. HSD rats presented obesity, which was characterized by an increased body weight and adiposity index. Obesity was associated with steatosis and a reduced level of hepatic GST, SOD and vitamin C. Copaiba oleoresin supplementation in HDS group was able to prevent obesity development and hepatic steatosis, and was associated to higher levels of GST, SOD and Vit C in the liver. Also, copaiba oleoresin decreased hepatic carbonylated protein levels. In conclusion, copaiba oleoresin prevented obesity development and improves hepatic redox system and steatosis. These results provided new insights that copaiba oleoresin may be a therapeutic natural compound feasible and beneficial for liver protection in diet-induced obesity.
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