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Current Topics in Phytochemistry   Volumes    Volume 16 
Chemical characterization, antioxidant, tyrosinase and elastase inhibitory activities of Colutea arborescens aerial parts guided by chemical and biological assays
Marie Schmitt, Abdulmagid Alabdul Magid, Nicolas Etique, Laurent Duca, Jane Hubert, Jean-Marc Nuzillard, Laurence Voutquenne-Nazabadioko
Pages: 91 - 103
Number of pages: 13
Current Topics in Phytochemistry
Volume 16 

Copyright © 2020 Research Trends. All rights reserved

This study presents the bio-guided chemical investigation of 80% methanol extract of aerial parts of bladder tree or Colutea arborescens. Liquid-liquid partitioning in solvents of increasing polarity combined with biological screening showed that the EtOAc and n-BuOH soluble fractions were the most active parts of the extract. These fractions were chemically profiled by a 13C NMR-based dereplication method, resulting in the identification of fifteen compounds. The dereplication process was completed by purification of minor compounds of the n-BuOH fraction. Fourteen known compounds (114) were isolated, including two tri-glycosylated flavonoids containing an apiofuranose unit (12 and 14). Their structures were elucidated by spectroscopic methods including 1D and 2D NMR and high-resolution electrospray ionization mass spectrometry. The antioxidant activity of fractions and isolated compounds were evaluated using 2,2,1-diphenyl-1-picrylhydrazyl and hydroxyl radicals scavenging and by cupric ion reducing antioxidant capacity assays. In parallel, their inhibitory properties against mushroom tyrosinase and human neutrophil elastase enzymes were assessed. Quercetin-type flavonoids showed the best antioxidant activities and a tri-glycosylated quercetin exhibited both antioxidant and anti-elastase activities. Phenylethyl-glucoside exhibited a significant tyrosinase inhibitory activity.
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