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Current Trends in Neurology   Volumes    Volume 17 
Application of TELC model to neurology: Review and commentary responding to Silverstein’s critique
James Weifu Lee
Pages: 83 - 98
Number of pages: 16
Current Trends in Neurology
Volume 17 

Copyright © 2023 Research Trends. All rights reserved

This article reviews the application of the transmembrane-electrostatically localized protons/ cations charges (TELC) model to better understand neuroscience, in addition to addressing some interesting comments from Silverstein’s critique. The application of the TELC model has yielded better understanding of neural transmembrane potential. At the resting transmembrane potential of −70 mV, the TELC density on extracellular membrane surface has now been calculated to be 3900 (protons + cations) per μm2. At the stimulation threshold level (−55 mV), the TELC density was calculated to be 3100 (protons + cations) per μm2. This is a significant result since it shows, for the first time, that a neural transmembrane potential change from the resting potential (−70 mV) to the stimulation threshold level (-55 mV) requires a change of TELC density by −800 charges (protons + cations) per μm2 from 3900 to 3100 charges per μm2 on the extracellular membrane surface to induce an action potential spike. It is the TELC that translates to the transmembrane potential (V). Overall, the TELC-based neural transmembrane potential equation represents a complementary development to the Goldman-Hodgkin-Katz equation.
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