Liposarcoma is a relatively common soft tissue sarcoma, but primary pulmonary liposarcomas are extremely rare, especially for the dedifferentiated subtype. We report the case of a 44‑year‑old African woman, healed from SARS-CoV-2, who presented a 8 cm right lung hilar mass and underwent a right intrapericardial pneumonectomy with diaphragmatic and pleural resection. The histopathologic examination confirmed the diagnosis of dedifferentiated primary pulmonary liposarcoma. The patient recovered well having an uncomplicated postoperative course. This case study confirms the effectiveness of pneumonectomy as treatment for primary pulmonary dedifferentiated liposarcoma. However, more studies have to be conducted on its best treatment because very few cases are reported in literature.