Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Trends in Organic Chemistry   Volumes    Volume 18 
Abstract
Facile synthesis of arylsulfonates from phenol derivatives and sulfonyl chlorides
Felix N. Ngassa, Sean Riley, Tsvetelina P. Atanasova, Abdurahman O. Ahmed, Stacey Kerr, Tyler A. Cooley, Ibrahim Al Shaikh Dawood, Ethan R. Austhof, Jonah R. J. Duran, Mitch Franklin
Pages: 1 - 14
Number of pages: 14
Trends in Organic Chemistry
Volume 18 

Copyright © 2017 Research Trends. All rights reserved

ABSTRACT
 
The C-O bond of phenol can be activated by reaction with arylsulfonyl chlorides to yield the corresponding arylsulfonates that can be used as electrophilic partners in subsequent reactions. Arylsulfonates can be conveniently synthesized from inexpensive phenol derivatives and sulfonyl chlorides. Moreover, their crystalline nature makes arylsulfonates easier than other electrophiles to purify and store over a long period of time. Although arylsulfonates are inferior to triflates in terms of electrophilicity, triflates are better leaving groups compared to sulfonates; arylsulfonates however have greater economical advantages over triflates. Facile synthesis of different arylsulfonates from various arylsulfonyl chlorides and phenol are reported. What is unique about the synthesis is that very good to excellent yields of arylsulfonates were obtained without the use of column chromatography. A more efficient purification technique was developed based on recrystallization. Using 2,4-dinitrophenyl 4-methylbenzenesulfonate and various amines, initial experiments have shown greater regioselectivity for the SNAr products.
View Full Article  


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms