Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Trends in Organic Chemistry   Volumes    Volume 18 
Single enantiomers from racemates: Lipase-catalysed kinetic resolution and in situ stereoinversion
Elisabeth E. Jacobsen, Thorleif Anthonsen
Pages: 71 - 83
Number of pages: 13
Trends in Organic Chemistry
Volume 18 

Copyright © 2017 Research Trends. All rights reserved

Kinetic resolution catalysed by lipases is a well suited strategy in order to provide enantiopure organic compounds. Factors affecting the enantiomeric ratio, the E-value, such as substrate structure, temperature effects, effects due to reaction media, significance of acyl donor, water activity of organic solvents and immobilisation of the catalyst, are discussed. Allosteric effects caused by chemicals in the reaction medium, which may influence the action of the enzyme catalyst are briefly discussed. Dynamic kinetic resolution and in situ stereoinversion methods that can be used to obtain more than 50% yield of a kinetic resolution are also discussed. The determination of the absolute configuration of the produced enantiomers based on enzyme preferences is an important issue.
Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms